Glycyrrhiza flavescens subsp antalyensis exerts antiproliferative effects on melanoma cells via altering TNF-alpha and IFN-alpha levels

Aydemir E., Oz E. S., GÖKTÜRK R. S., ÖZKAN G., FIŞKIN K.

FOOD AND CHEMICAL TOXICOLOGY, vol.49, no.4, pp.820-828, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 4
  • Publication Date: 2011
  • Doi Number: 10.1016/j.fct.2010.12.003
  • Journal Name: FOOD AND CHEMICAL TOXICOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.820-828
  • Keywords: Apoptosis, Caspase, Glycyrrhiza, Interferon-gamma, Melanoma, Tumor necrosis factor, NF-KAPPA-B, IN-VITRO, NATURAL-PRODUCTS, DRUG-RESISTANCE, ANTICANCER ACTIVITY, APOPTOSIS, EXTRACT, INDUCTION, ACTIVATION, MECHANISMS
  • Akdeniz University Affiliated: Yes

Abstract

Glycyrrhiza species possess preventive and therapeutic potentials against various cancers. In the present study, we have evaluated regulation of apoptotic cell death by aqueous extracts of leaf and flower of an endemic Glycyrrhiza species; Glycyrrhiza flavescens subsp. antalyensis, in mouse melanoma cell lines. Both leaf and flower extracts induced apoptosis in terms of induction of caspase-3 activity, TNF-alpha and IFN-gamma release. Concentrations of both TNF-alpha and IFN-gamma in extract-treated groups were significantly and dose dependently exalted as compared to their relative controls. The effects of extracts on caspase-3, TNF-alpha and IFN-gamma processes mediate the plausible mechanism of apoptosis induction of G. flavescens subsp. antalyensis. (C) 2010 Elsevier Ltd. All rights reserved.