2100-MHz electromagnetic fields have different effects on visual evoked potentials and oxidant/antioxidant status depending on exposure duration

Hidisoglu E., GOK D., ER H., Akpinar D., UYSAL F., AKKOYUNLU G., ...Daha Fazla

Brain Research, cilt.1635, ss.1-11, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1635
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.brainres.2016.01.018
  • Dergi Adı: Brain Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1-11
  • Anahtar Kelimeler: Electromagnetic fields, Visual evoked potentials, Oxidative stress, Antioxidant, Nitric oxide, 3G MOBILE PHONES, OXIDATIVE STRESS, LIPID-PEROXIDATION, NITRIC-OXIDE, RADIOFREQUENCY RADIATION, CELLULAR PHONES, LIPOIC ACID, RAT-BRAIN, EEG, PROTEIN
  • Akdeniz Üniversitesi Adresli: Evet

Özet

© 2016 Elsevier B.V. All rights reserved.The purpose of the present study was to investigate the duration effects of 2100-MHz electromagnetic field (EMF) on visual evoked potentials (VEPs) and to assess lipid peroxidation (LPO), nitric oxide (NO) production and antioxidant status of EMF exposed rats. Rats were randomized to following groups: Sham rats (S1 and S10) and rats exposed to 2100-MHz EMF (E1 and E10) for 2 h/day for 1 or 10 weeks, respectively. At the end of experimental periods, VEPs were recorded under anesthesia. Brain thiobarbituric acid reactive substances (TBARS) and 4-hydroxy-2-nonenal (4-HNE) levels were significantly decreased in the E1 whereas increased in the E10 compared with their control groups. While brain catalase (CAT), glutathione peroxidase (GSH-Px) activities and NO and glutathione (GSH) levels were significantly increased in the E1, reduction of superoxide dismutase (SOD) activity was detected in the same group compared with the S1. Conversely, decreased CAT, GSH-Px activities and NO levels were observed in the E10 compared with the S10. Latencies of all VEP components were shortened in the E1 compared with the S1, whereas latencies of all VEP components, except P1, were prolonged in the E10 compared with the S10. There was a positive correlation between all VEP latencies and brain TBARS and 4-HNE values. Consequently, it could be concluded that different effects of EMFs on VEPs depend on exposure duration. In addition, our results indicated that short-term EMF could provide protective effects, while long-term EMF could have an adverse effect on VEPs and oxidant/antioxidant status.