Quantitative analysis of BIN-specific CD4+T cells before and after kidney transplantation

MUTLU E., KÖKSOY S., MUTLU D., YILMAZ V. C., KOÇAK H., Dinckan A., ...Daha Fazla

TRANSPLANT IMMUNOLOGY, cilt.33, sa.1, ss.20-26, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.trim.2015.05.005
  • Dergi Adı: TRANSPLANT IMMUNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.20-26
  • Anahtar Kelimeler: BKV, Renal transplantation, ELISPOT, Mixture of overlapping peptide pool, BK VIRUS-INFECTION, CELLULAR IMMUNE-RESPONSE, LARGE T-ANTIGEN, RENAL-TRANSPLANTATION, RISK-FACTORS, POLYOMAVIRUS, RECIPIENTS, NEPHROPATHY, REPLICATION, INTERPLAY
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: BK virus (BIN) is the main infectious cause of renal allograft dysfunction. Although recent studies showed an inverse correlation between BIN-specific T-cell responses and viral load after transplantation, the importance of pre-transplant response in the process of virus reactivation has only been studied once. In this study, we aimed to determine whether pre-transplant CD4 + T-cell response can be used for prediction of BIN reactivation and BKV nephropathy (BKVN), by a method that can practically be used in routine patient monitoring.