Quantitative analysis of BIN-specific CD4+T cells before and after kidney transplantation
TRANSPLANT IMMUNOLOGY, vol.33, no.1, pp.20-26, 2015 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 33 Issue: 1
- Publication Date: 2015
- Doi Number: 10.1016/j.trim.2015.05.005
- Journal Name: TRANSPLANT IMMUNOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.20-26
- Keywords: BKV, Renal transplantation, ELISPOT, Mixture of overlapping peptide pool, BK VIRUS-INFECTION, CELLULAR IMMUNE-RESPONSE, LARGE T-ANTIGEN, RENAL-TRANSPLANTATION, RISK-FACTORS, POLYOMAVIRUS, RECIPIENTS, NEPHROPATHY, REPLICATION, INTERPLAY
- Akdeniz University Affiliated: Yes
Abstract
Background: BK virus (BIN) is the main infectious cause of renal allograft dysfunction. Although recent studies showed an inverse correlation between BIN-specific T-cell responses and viral load after transplantation, the importance of pre-transplant response in the process of virus reactivation has only been studied once. In this study, we aimed to determine whether pre-transplant CD4 + T-cell response can be used for prediction of BIN reactivation and BKV nephropathy (BKVN), by a method that can practically be used in routine patient monitoring.