Serum N-Desmethylcitalopram Concentrations are Associated with the Clinical Response to Citalopram of Patients with Major Depression

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ÖZBEY G., Yücel B., BODUR N. E., TAYCAN S. E., ARSLAN T., CERIT N., ...More

PSYCHIATRY INVESTIGATION, vol.15, no.3, pp.313-319, 2018 (SCI-Expanded, SSCI, Scopus)

  • Publication Type: Article / Article
  • Volume: 15 Issue: 3
  • Publication Date: 2018
  • Doi Number: 10.30773/pi.2017.05.22
  • Journal Name: PSYCHIATRY INVESTIGATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.313-319
  • Keywords: Serum concentration, Citalopram, N-desmethylcitalopram, Efficacy, Tolerability, Major depression, ANTIDEPRESSANT DRUGS, METABOLITES, POPULATION, PSYCHIATRY, INHIBITORS
  • Open Archive Collection: AVESIS Open Access Collection
  • Akdeniz University Affiliated: Yes

Abstract

Objective Citalopram (CITA) is a widely used and well-tolerated selective serotonin reuptake inhibitor. The aim of the study was to evaluate the possible influences of serum concentrations of CITA and its major metabolite n-desmethylcitalopram (NDCITA) on the efficacy and tolerability of CITA in patients with major depressive disorder.