Protective Effects of N-Acetyl Cysteine against Paclitaxel-Induced Cardiotoxicity Through Modulation of Transient Receptor Potential Melastatin 2 Channels

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ÖNCEL C. R., Ovey I. S.

GAZI MEDICAL JOURNAL, vol.30, no.2, pp.155-161, 2019 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 2
  • Publication Date: 2019
  • Doi Number: 10.12996/gmj.2019.39
  • Journal Name: GAZI MEDICAL JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Page Numbers: pp.155-161
  • Keywords: Apoptosis, paclitaxel, cardiomyocyte, transient receptor potential melastatin 2, N-acetyl cysteine, OXIDATIVE STRESS, TRPM2 CHANNEL, MITOCHONDRIAL DYSFUNCTION, MYOCARDIAL-INFARCTION, CALCIUM OSCILLATIONS, CARDIAC TOXICITY, CA2+ ENTRY, APOPTOSIS, ACETYLCYSTEINE, ACTIVATION
  • Akdeniz University Affiliated: Yes

Abstract

Aim : In our study, we investigated the paclitaxel induced cardiotoxicity and alterations in Ca2+ influx, oxidative stress and apoptosis through transient receptor potential melastatin 2 (TRPM2) channels and modulator role of N-acetyl cysteine (NAC) in cardiomyocytes.