The protective effect of aminoguanidine on erectile function in diabetic rats is not related to the timing of treatment

Usta M., Bivalacqua T., Koksal I., Toptas B., Surmen S., Hellstrom W.

BJU INTERNATIONAL, cilt.94, sa.3, ss.429-432, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 94 Sayı: 3
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1111/j.1464-410x.2004.04937.x
  • Dergi Adı: BJU INTERNATIONAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.429-432
  • Anahtar Kelimeler: aminoguanidine, advanced glycation end products, diabetes mellitus, erectile dysfunction, GLYCATION END-PRODUCTS, SMOOTH-MUSCLE RELAXATION, NITRIC-OXIDE, SKIN COLLAGEN, GLYCOXIDATION, DYSFUNCTION, TISSUE, INOS
  • Akdeniz Üniversitesi Adresli: Evet

Özet

To assess the accumulation of advanced glycation end products (AGEs) in streptozotocin (STZ)-induced diabetic rat cavernosal tissue, and to determine whether the protective effect of aminoguanidine (AG) on erectile function is related to the timing of treatment, as the accumulation of AGEs in the penis may be important in the pathogenesis of diabetes mellitus-induced erectile dysfunction, and prolonged treatment with AG (a selective AGE inhibitor), prevents erectile dysfunction in this situation.