Rapamycin administration during normal and diabetic pregnancy effects the mTOR and angiogenesis signaling in the rat placenta

Ozmen A., Kipmen-Korgun D., KORGUN E. T.

JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION, cilt.48, sa.3, ss.193-199, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48 Sayı: 3
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.jogoh.2018.12.003
  • Dergi Adı: JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.193-199
  • Anahtar Kelimeler: mTOR, Rapamycin, Diabetes, Placenta, Angiogenesis, EXPRESSION, PATHWAY, GROWTH
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Objective: The mammalian target of rapamycin (mTOR) signaling pathway has newly been recommended to be a nutrient sensor in the placenta. It is speculated that mTORC1 may be activated in diabetes, associated with increased placental nutrient availability. Thus, we aimed to investigate the mTOR signaling pathway both in diabetic and non-diabetic placenta and searched for the alterations of angiogenic factors VEGF, VEGFRI and VEGFR2.