Rapamycin administration during normal and diabetic pregnancy effects the mTOR and angiogenesis signaling in the rat placenta

Ozmen A., Kipmen-Korgun D., KORGUN E. T.

JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION, vol.48, no.3, pp.193-199, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 3
  • Publication Date: 2019
  • Doi Number: 10.1016/j.jogoh.2018.12.003
  • Journal Name: JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.193-199
  • Keywords: mTOR, Rapamycin, Diabetes, Placenta, Angiogenesis, EXPRESSION, PATHWAY, GROWTH
  • Akdeniz University Affiliated: Yes

Abstract

Objective: The mammalian target of rapamycin (mTOR) signaling pathway has newly been recommended to be a nutrient sensor in the placenta. It is speculated that mTORC1 may be activated in diabetes, associated with increased placental nutrient availability. Thus, we aimed to investigate the mTOR signaling pathway both in diabetic and non-diabetic placenta and searched for the alterations of angiogenic factors VEGF, VEGFRI and VEGFR2.