Rapamycin administration during normal and diabetic pregnancy effects the mTOR and angiogenesis signaling in the rat placenta

Ozmen, ASLI; Kipmen-Korgun, DİJLE; KORGUN, EMİN

doi:10.1016/j.jogoh.2018.12.003

Rapamycin administration during normal and diabetic pregnancy effects the mTOR and angiogenesis signaling in the rat placenta

Ozmen A., Kipmen-Korgun D., KORGUN E. T.

JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION, vol.48, no.3, pp.193-199, 2019 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 48 Issue: 3
Publication Date: 2019
Doi Number: 10.1016/j.jogoh.2018.12.003
Journal Name: JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.193-199
Keywords: mTOR, Rapamycin, Diabetes, Placenta, Angiogenesis, EXPRESSION, PATHWAY, GROWTH
Akdeniz University Affiliated: Yes

Abstract

Objective: The mammalian target of rapamycin (mTOR) signaling pathway has newly been recommended to be a nutrient sensor in the placenta. It is speculated that mTORC1 may be activated in diabetes, associated with increased placental nutrient availability. Thus, we aimed to investigate the mTOR signaling pathway both in diabetic and non-diabetic placenta and searched for the alterations of angiogenic factors VEGF, VEGFRI and VEGFR2.