Neonatal multiple sulfatase deficiency with a novel mutation and review of the literature
Turkish Journal of Pediatrics, cilt.56, sa.4, ss.418-422, 2014 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 56 Sayı: 4
- Basım Tarihi: 2014
- Dergi Adı: Turkish Journal of Pediatrics
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.418-422
- Anahtar Kelimeler: Ichthyosis, Lysosomal storage disease, Multiple sulfatase deficiency, Neonatal
- Akdeniz Üniversitesi Adresli: Evet
Özet
© 2014, Turkish Journal of Pediatrics. All rights reserved.Multiple sulfatase deficiency is a rare autosomal recessive disorder in which affected individuals present a complex phenotype due to the impaired activity of all sulfatases. There are different types of multiple sulfatase deficiency; among them, the neonatal form is the most severe, with a broad range of mucopolysaccharidosis-like symptoms and death within the first year of life. The disorder is caused by homozygous or compound heterozygous mutations in the sulfatase-modifying factor-1 (SUMF1) gene. In this article, we describe a non-ichthyotic neonatal multiple sulfatase deficiency patient with a novel mutation in the SUMF1 gene. The missense mutation c.777C>G, for which the patient was homozygous, had been caused by a p.N259K amino acid substitution. We evaluated the patient using clinical findings, neuroimaging studies and molecular analysis via the literature; we also wanted to note the difficulties in the diagnosis of this rare disease.