Paraoxonase/arylesterase ratio, PON1 192Q/R polymorphism and PON1 status are associated with increased risk of ischernic stroke

Demirdogen, Birsen; Turkanoglu, AYSUN; Bek, Semai; Sanisoğlu, Yavuz; Demirkaya, Seref; Vural, Okay; Arinc, Emel; ADALI, ORHAN

doi:10.1016/j.clinbiochem.2007.08.010

Paraoxonase/arylesterase ratio, PON1 192Q/R polymorphism and PON1 status are associated with increased risk of ischernic stroke

Demirdogen B. C., Turkanoglu A., Bek S., Sanisoğlu Y., Demirkaya S., Vural O., ...Daha Fazla

CLINICAL BIOCHEMISTRY, cilt.41, sa.1-2, ss.1-9, 2008 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 41 Sayı: 1-2
Basım Tarihi: 2008
Doi Numarası: 10.1016/j.clinbiochem.2007.08.010
Dergi Adı: CLINICAL BIOCHEMISTRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1-9
Anahtar Kelimeler: paraoxonase, polymorphism, ischemic stroke, risk factors, genes, atherosclerosis, SERUM PARAOXONASE ACTIVITY, CORONARY-ARTERY-DISEASE, LOW-DENSITY-LIPOPROTEIN, MYOCARDIAL-INFARCTION, GENE POLYMORPHISMS, OXIDATIVE STRESS, VASCULAR-DISEASE, HEART-DISEASE, HUMPONA GENE, ARYLESTERASE
Akdeniz Üniversitesi Adresli: Hayır

Özet

Objectives: In recent years, importance of enzyme activity measurements, in addition to genotyping, in epidemiological studies relating paraoxonase 1 (PON1) and vascular disease was emphasized. This is the first report evaluating paraoxonase and arylesterase activities as risk factors for ischemic stroke. In addition, PON1 192Gln(Q)/Arg(R) and 55Leu(L)/Met(M) polymorphisms were also analyzed.