Paraoxonase/arylesterase ratio, PON1 192Q/R polymorphism and PON1 status are associated with increased risk of ischernic stroke

Demirdogen, Birsen; Turkanoglu, AYSUN; Bek, Semai; Sanisoğlu, Yavuz; Demirkaya, Seref; Vural, Okay; Arinc, Emel; ADALI, ORHAN

doi:10.1016/j.clinbiochem.2007.08.010

Paraoxonase/arylesterase ratio, PON1 192Q/R polymorphism and PON1 status are associated with increased risk of ischernic stroke

Demirdogen B. C., Turkanoglu A., Bek S., Sanisoğlu Y., Demirkaya S., Vural O., ...More

CLINICAL BIOCHEMISTRY, vol.41, no.1-2, pp.1-9, 2008 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 41 Issue: 1-2
Publication Date: 2008
Doi Number: 10.1016/j.clinbiochem.2007.08.010
Journal Name: CLINICAL BIOCHEMISTRY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1-9
Keywords: paraoxonase, polymorphism, ischemic stroke, risk factors, genes, atherosclerosis, SERUM PARAOXONASE ACTIVITY, CORONARY-ARTERY-DISEASE, LOW-DENSITY-LIPOPROTEIN, MYOCARDIAL-INFARCTION, GENE POLYMORPHISMS, OXIDATIVE STRESS, VASCULAR-DISEASE, HEART-DISEASE, HUMPONA GENE, ARYLESTERASE
Akdeniz University Affiliated: No

Abstract

Objectives: In recent years, importance of enzyme activity measurements, in addition to genotyping, in epidemiological studies relating paraoxonase 1 (PON1) and vascular disease was emphasized. This is the first report evaluating paraoxonase and arylesterase activities as risk factors for ischemic stroke. In addition, PON1 192Gln(Q)/Arg(R) and 55Leu(L)/Met(M) polymorphisms were also analyzed.