Akademik Veri Yönetim Sistemi
International Journal of Medical Physics, Clinical Engineering and Radiation Oncology, cilt.9, sa.4, ss.157-164, 2020 (Hakemli Dergi)
Aims: The current study aimed to evaluate the efficacy, side effects of radiotherapy
and factors influencing treatment outcome in patients received radiotherapy
for cerebral meningiomas. Methods and Material: In the last two
decades, a total of 35 patients with cerebral meningioma who received radiotherapy
in our clinic were evaluated statistically in terms of survival, toxicity
and prognostic factors. The records of patients diagnosed with cerebral meningioma
who underwent postoperative radiotherapy were retrospectively analyzed.
Statistical analysis used: Statistical comparisons were made using IBM
SPSS v24.0. Kaplan-Meier method was used to compare survival times. Results:
Five of the patients had grade I meningioma showing recurrence, 18
were grade II meningioma and 12 were grade III meningioma. Patients were
treated with 54 or 60 Gy adjuvant radiotherapy with 2 Gy daily fractions according
to histopathological grade and operation type. Three and five-year
overall survival rates were 56% and 40%, respectively and median overall survival
was 36 months. Progression was observed in 15 of the 35 patients included
in the study. Three and five-year progression-free survival (PFS) rates
of the patients were 56% and 50%, respectively. There was a statistically significant
correlation between histopathological grade and overall survival among
patients. However; no statistical difference found in overall survival of patients
in terms of tumor location, operation type and age. Conclusions: In
the treatment of cerebral meningiomas, changes in radiotherapy dose and field
designs can be predicted according to the tumor grade and operation type. In
addition, it is thought that large scale studies are needed to determine prognostic
factors more meticulously.