Effects of Human Placental Amnion Derived Mesenchymal Stem Cells on Proliferation and Apoptosis Mechanisms in Chronic Kidney Disease in the Rat

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Cetinkaya B., UNEK G., Kipmen-Korgun D., KÖKSOY S., KORGUN E. T.

INTERNATIONAL JOURNAL OF STEM CELLS, vol.12, no.1, pp.151-161, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.15283/ijsc18067
  • Journal Name: INTERNATIONAL JOURNAL OF STEM CELLS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.151-161
  • Keywords: Human amnion derived mesenchymal stem cells, Chronic kidney failure, Apoptosis, Proliferation, Rat, CHINESE HERBS NEPHROPATHY, ARISTOLOCHIC ACID, MOLECULAR-MECHANISMS, EPITHELIAL-CELLS, TUBULAR INJURY, RENAL FIBROSIS, STROMAL CELLS, DNA-ADDUCTS, MODEL, ISCHEMIA/REPERFUSION
  • Akdeniz University Affiliated: Yes

Abstract

Background and Objectives: The feature of chronic kidney failure (CKF) is loss of kidney functions due to erosion of healthy tissue and fibrosis. Recent studies showed that Mesenchymal stem cells (MSCs) differentiated into tubular epithelial cells thus renal function and structures rcnewed.Furthermore, MSCs protect renal function in CKF. Therefore, we aimed to investigate whether human amnion-derived mesenchymal stem cells (hAMSCs) can repair fibrosis and determine the effects on proliferation and apoptosis mechanisms in chronic kidney failure.