Serum hepcidin / ferroportin levels in bipolar disorder and schizophrenia
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, vol.68, 2021 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 68
- Publication Date: 2021
- Doi Number: 10.1016/j.jtemb.2021.126843
- Journal Name: JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
- Keywords: Iron, Ferroportin, Hepcidin, Schizophrenia, Antipsychotics, RATING-SCALE, TARDIVE-DYSKINESIA, PARKINSONS-DISEASE, ALZHEIMERS-DISEASE, OXIDATIVE STRESS, IRON, METABOLISM, ERYTHROPHAGOCYTOSIS, 6-HYDROXYDOPAMINE, ANTIPSYCHOTICS
- Akdeniz University Affiliated: Yes
Abstract
Background: Despite several alternatives for cellular iron influx, the only mechanism for cellular iron efflux is ferroportin mediated active transport. In cases of ferroportin dysfunction, iron accumulates in the cell and causes ferroptosis. Hepcidin suppresses ferroportin levels and inflammatory activation increases hepcidin production. Mild inflammation in schizophrenia and bipolar disorder may alter hepcidin and ferroportin.