Serum hepcidin / ferroportin levels in bipolar disorder and schizophrenia

Altun I. K., Atagun M. I., ERDOĞAN A., Yenilmez D. O., Yusifova A., Senat A., ...Daha Fazla

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, cilt.68, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 68
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.jtemb.2021.126843
  • Dergi Adı: JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Iron, Ferroportin, Hepcidin, Schizophrenia, Antipsychotics, RATING-SCALE, TARDIVE-DYSKINESIA, PARKINSONS-DISEASE, ALZHEIMERS-DISEASE, OXIDATIVE STRESS, IRON, METABOLISM, ERYTHROPHAGOCYTOSIS, 6-HYDROXYDOPAMINE, ANTIPSYCHOTICS
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: Despite several alternatives for cellular iron influx, the only mechanism for cellular iron efflux is ferroportin mediated active transport. In cases of ferroportin dysfunction, iron accumulates in the cell and causes ferroptosis. Hepcidin suppresses ferroportin levels and inflammatory activation increases hepcidin production. Mild inflammation in schizophrenia and bipolar disorder may alter hepcidin and ferroportin.