Exaggerated interictal cerebrovascular reactivity but normal blood flow velocities in migraine without aura

Dora B., Balkan S.

CEPHALALGIA, cilt.22, sa.4, ss.288-290, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 4
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1046/j.1468-2982.2002.00365.x
  • Dergi Adı: CEPHALALGIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.288-290
  • Anahtar Kelimeler: breath holding index, cerebral blood flow velocity, cerebrovascular reactivity, migraine without aura, transcranial Doppler ultrasound, TRANSCRANIAL DOPPLER ULTRASOUND, HEADACHE-FREE MIGRAINEURS
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Interictal cerebrovascular reactivity and blood flow velocities were tested in 23 patients with migraine without aura and 10 age- and sex-matched healthy controls by using the breath holding index (BHI). The mean systolic, diastolic and mean velocities and pulsatility indices were not different in the controls and patients. The BHI was found to be significantly greater (P =0011) in the patients (1.64 +/- 0.33) compared with the controls (1.26 +/- 0.37), showing an exaggerated reactivity to hypercapnia in migraineurs. Reactivity to pCO(2) theoretically depends on pre-existing arteriolar tone and thereby on baseline velocity. Our finding of similar blood flow velocities in controls and patients suggests that the underlying cause for this high reactivity may not be an increased vasotonus but an increased sensitivity to changes in blood CO2 levels.