CTLA-4
TURK DERMATOLOJI DERGISI-TURKISH JOURNAL OF DERMATOLOGY, vol.11, no.2, pp.75-79, 2017 (ESCI, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 11 Issue: 2
- Publication Date: 2017
- Doi Number: 10.4274/tdd.3226
- Journal Name: TURK DERMATOLOJI DERGISI-TURKISH JOURNAL OF DERMATOLOGY
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.75-79
- Keywords: CTLA-4, autoimmunity, gene, polymorphism, pemphigus, Turkey, ENDEMIC PEMPHIGUS FOLIACEUS, GENE POLYMORPHISM, AUTOIMMUNE, SUSCEPTIBILITY, ASSOCIATION
- Open Archive Collection: AVESIS Open Access Collection
- Akdeniz University Affiliated: Yes
Abstract
Objective: Pemphigus, expressing a life-threatening blistering disease, result from autoantibodies against the proteins that mediate intercellular adhesion in desmosomes, namely desmoglein 1 and/or 3. The importance of cytotoxic T lymphocyte-associated antigen (CTLA)-4 in negative regulation of T lymphocytes, which take part in this autoimmune reaction, is well known. Gene polymorphisms regarding this molecule affect autoimmunity. We aimed to determine whether CTLA-4 +49 A/G, -318 C/T, -1661 A/G and CT60 A/G gene polymorphisms cause susceptibility to pemphigus in Turkish population.