CTLA-4

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Bacanli A., KARAKAS A. A., Sallakci N., Topal S. G., Aydin F., UZUN S., ...Daha Fazla

TURK DERMATOLOJI DERGISI-TURKISH JOURNAL OF DERMATOLOGY, cilt.11, sa.2, ss.75-79, 2017 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.4274/tdd.3226
  • Dergi Adı: TURK DERMATOLOJI DERGISI-TURKISH JOURNAL OF DERMATOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.75-79
  • Anahtar Kelimeler: CTLA-4, autoimmunity, gene, polymorphism, pemphigus, Turkey, ENDEMIC PEMPHIGUS FOLIACEUS, GENE POLYMORPHISM, AUTOIMMUNE, SUSCEPTIBILITY, ASSOCIATION
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Objective: Pemphigus, expressing a life-threatening blistering disease, result from autoantibodies against the proteins that mediate intercellular adhesion in desmosomes, namely desmoglein 1 and/or 3. The importance of cytotoxic T lymphocyte-associated antigen (CTLA)-4 in negative regulation of T lymphocytes, which take part in this autoimmune reaction, is well known. Gene polymorphisms regarding this molecule affect autoimmunity. We aimed to determine whether CTLA-4 +49 A/G, -318 C/T, -1661 A/G and CT60 A/G gene polymorphisms cause susceptibility to pemphigus in Turkish population.