Akademik Veri Yönetim Sistemi
Turkiye Klinikleri Journal of Medical Sciences, cilt.32, sa.1, ss.80-87, 2012 (SCI-Expanded)
Objective: Angiogenesis is a major factor in the development of solid tumors, such as endometrial cancer. Vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) are important cytokines that stimulate angiogenesis in vivo. The aim of the current study was to de-termine VEGF and COX-2 expression in endometrial adenocarcinomas and to investigate the rela-tionship between these parameters and clinicopathologic parameters. Material and Methods: Sections obtained from paraffin-embedded tissues in archive material of 23 patients who were di-agnosed with endometrial carcinoma were retrospectively evaluated. VEGF and COX-2 expression levels in tumor cells and surrounding stroma on the tumor samples were determined by immuno- histochemistry. Results: VEGF and COX-2 were expressed both in the cytoplasm of tumor cells and in the stromal cells, but in a lower degree. There was a significant positive correlation between VEGF expressions of cancer cells and the stroma (r= 0.705, p< 0.01). A negative correlation was found between histological grade of the tumor and VEGF expression of cancer cells (r= -0.622, p= 0.002). A negative correlation was determined between myometrial invasion of the tumor and COX-2 expression of cancer cells (r= -0.441, p= 0.035). Conclusion: Both VEGF and COX-2 were ex-pressed by both tumor cells and stromal cells in endometrial cancer. While VEGF expression showed a negative correlation with the tumor grade, COX-2 expression exhibited a negative cor-relation with the myometrial invasion of the tumor. No correlation was determined between their expressions and other clinicopathologic prognostic parameters. © 2012 by Türkiye Klinikleri.