Eosinophilic tubulointerstitial nephritis on treatment with isotretinoin

KAYA AKSOY G., KOYUN M., AKKAYA B., ÇOMAK E., Gemici A., AKMAN S.

EUROPEAN JOURNAL OF PEDIATRICS, cilt.175, sa.12, ss.2005-2006, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 175 Sayı: 12
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s00431-016-2778-7
  • Dergi Adı: EUROPEAN JOURNAL OF PEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2005-2006
  • Anahtar Kelimeler: Acute tubulointerstitial nephritis, Isotretinoin, Drug-related tubulointerstitial nephritis, Renal failure, ORAL ISOTRETINOIN
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Drug- related acute tubulointerstitial nephritis is one of the most common causes of childhood acute renal failures which originate from kidneys. Sixteen- year old male patient with the history of isotretinoin use for the last 3 months was admitted with acute renal failure. Renal function parameters were measured as follows: blood urea nitrogen 21 mg/dL, serum creatinine 1.68 mg/dL, cystatin C 1.15 mg/L, and estimated glomerular filtration rate based on cystatin C 56.5 mL/min/1.73 m2. The patient whom pathological signs of renal biopsy sections revealed interstitial mononuclear cell and eosinophilic infiltration was diagnosed with acute tubulointerstitial nephritis.