A PARADOX FROM A NEUROTRANSMITTER: THE OPPOSITE EFFECTS OF SUBSTANCE P AND ITS PHYSIOLOGICAL FRAGMENTS SP (1-7) AND SP (9-11) ON THE PROLIFERATION OF HUMAN BREAST CANCER CELLS AND THE MIGRATION CAPABILITIES OF HUVEC CELLS

Kocak O., Simsek E.

WORLD CANCER RESEARCH JOURNAL, vol.9, pp.1-12, 2022 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 9
  • Publication Date: 2022
  • Journal Name: WORLD CANCER RESEARCH JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI)
  • Page Numbers: pp.1-12
  • Keywords: Substance P, N-terminal Fragment SP (1-7), C-terminal Fragment SP (9-11), Proliferation, Anti-Angiogenesis, RECEPTOR ANTAGONISTS, NK1 RECEPTOR, EXPRESSION, THALIDOMIDE, ENDOSTATIN
  • Akdeniz University Affiliated: Yes

Abstract

Objective: Substance P (SP) is a neurotransmitter peptide, and it is known to play a major role in neurogenic inflammation, inducing local inflammatory responses, cancer, and angiogenesis. It has been previously demonstrated that SP possesses a wide range of pharmacological effects including induced cancer cell proliferation and triggered angiogenic response of tumors. However, there is no published work regarding the proliferative effects of its physiological fragments [N-terminal fragment SP (1-7) and C-terminal fragment SP (9-11)] not only on cancer cells but also on human umbilical vein endothelial cells (HUVECs).