Characterizing gradient echo signal decays in gynecologic cancers at 3T using a Gaussian augmentation of the monoexponential (GAME) model

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ÇİRİŞ P., Balasubramanian M., Damato A. L., SEETHAMRAJU R. T., Tempany-Afdhal C. M., Mulkern R. V., ...More

JOURNAL OF MAGNETIC RESONANCE IMAGING, vol.44, no.4, pp.1020-1030, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.1002/jmri.25226
  • Journal Name: JOURNAL OF MAGNETIC RESONANCE IMAGING
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1020-1030
  • Keywords: biophysical modeling, Lorentzian, Gaussian, transverse relaxation, blood oxygenation, gynecologic cancers, UTERINE CERVICAL-CANCER, TUMOR OXYGEN-TENSION, VASCULAR DENSITY, CELL-DENSITY, BOLD-MRI, 3.0 T, HYPOXIA, RELAXATION, RADIOTHERAPY, CARCINOMA
  • Akdeniz University Affiliated: Yes

Abstract

PurposeTo assess whether mapping with a standard Monoexponential (ME) or a Gaussian Augmentation of the Monoexponential (GAME) decay model better characterizes gradient-echo signal decays in gynecological cancers after external beam radiation therapy at 3T, and evaluate implications of modeling for noninvasive identification of intratumoral hypoxia. Materials and Methods: Multi-gradient-echo signals were acquired on 25 consecutive patients with gynecologic cancers and three healthy participants during inhalation of different oxygen concentrations at 3T. Data were fitted with both ME and GAME models. Models were compared using F-tests in tumors and muscles in patients, muscles, cervix, and uterus in healthy participants, and across oxygenation levels.