Blood compatibility of artificial blood vessels probed by infrared spectroscopic imaging

Steiner G., Maitz M., TUNÇ S., Salzer R.

Conference on Biomedical Vibrational Spectroscopy III, San-Jose, Kostarika, 21 - 24 Ocak 2006, cilt.6093 identifier identifier

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Cilt numarası: 6093
  • Doi Numarası: 10.1117/12.644907
  • Basıldığı Şehir: San-Jose
  • Basıldığı Ülke: Kostarika
  • Anahtar Kelimeler: protein adsorption, protein conformations, fibrinogen, FTIR spectroscopic imaging, SECONDARY STRUCTURE, PROTEIN ADSORPTION, FORCE MICROSCOPY, FIBRINOGEN, SURFACES, IGG, FTIR
  • Akdeniz Üniversitesi Adresli: Evet

Özet

The determination of protein structure and function plays an important role in biomedical and biochemical research. Common techniques that. give full structural information do not permit in-vivo measurements. Infrared spectroscopy has a sufficient sensitivity to examine the structure of proteins solution under in-situ conditions and even on surfaces. However, measurements at few spots on the surface are not suitable to find out the blood compatibility of the protein layer, because the changes in conformation occur often in small domains. Here we report on the investigations of adsorbed fibrinogen with FTIR imaging. FTIR imaging permits an identification of coagulation spots in the micrometer range and the identification of coagulation spots on the implant material.