The effect of electroconvulsive therapy on neutrophyl/lymphocyte ratio

Canan F., Kurklu N., Gecici O., Kuloglu M.

JOURNAL OF MOOD DISORDERS, vol.6, no.1, pp.1-6, 2016 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.5455/jmood.20160218093328
  • Journal Name: JOURNAL OF MOOD DISORDERS
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1-6
  • Keywords: electroconvulsive therapy, neutrophil/lymphocyte ratio, inflammation, immunology, NEUTROPHIL-LYMPHOCYTE RATIO, NEUTROPHIL/LYMPHOCYTE RATIO, BIPOLAR DISORDER, IMMUNE FUNCTION, HIPPOCAMPUS, DEPRESSION, CYTOKINES, SYSTEM, SHOCK, ECT
  • Akdeniz University Affiliated: Yes

Abstract

Objective: Inflammatory and immune mechanisms are reported to play important roles in the pathophysiology of psychiatric disorders. Electroconvulsive therapy (ECT) is regarded as an effective treatment of not only depression, but also schizophrenia and mania, especially when there is no response to pharmacological interventions. Despite the common use of ECT, its mechanism of action is mostly unknown. Few studies examined the effect of ECT on inflammatory and immune functions. The neutrophillymphocyte ratio (NLR) is a simple and easily accessible indicator of the systemic inflammatory response. Our aim was to investigate whether a series of ECT sessions would change NLR in patients with major depression, bipolar disorder, or schizophrenia.