Akademik Veri Yönetim Sistemi
JOURNAL OF GERIATRIC ONCOLOGY, cilt.13, sa.8, ss.1264-1267, 2022 (SCI-Expanded)
Lung cancer, the third most common cancer, is the leading cause of cancer-related mortality and is frequently a disease of older patients [1]. As a result of the under-representation of older patients with lung cancer in clinical trials, there is a lack of scientific knowledge on how to select this patient group for different anticancer strategies [2]. It is critical to recommend appropriate treatment after evaluating frailty, life expectancy, and treatment-related potential toxicities for older patients with lung cancer. Comprehensive geriatric assessment (CGA) is the gold standard for multidimensional evaluation that determines medical, psychological, functional status, nutrition, cognition, social activity, support, and polypharmacy; however, this process is time-consuming [3]. Therefore, a two-step approach, beginning with a screening tool to select older patients with cancer who will benefit from CGA, has been proposed by the International Society of Geriatric Oncology (SIOG) [4]. The Geriatric-8 (G8) score, created for oncologists as a quick and useful screening tool for assessing the frailty of older patients [5], was found to have a high sensitivity in predicting abnormalities in the CGA and was also associated with survival and treatment-related complications [6]. Although G8 scores have been shown to be associated with overall survival (OS) after curative radiotherapy in older patients with cancer, the predictive value of G8 varies between various tumor types [7]. Regarding older patients with lung cancer, the diagnostic sensitivity of G8 is identified as reliable (89.8%) [8], and impaired G8 has been found to be an independent prognostic factor for OS in patients treated with chemotherapy or chemoradiotherapy (CRT) [9]. The prognostic significance of basic laboratory parameters such as hemoglobin, albumin, neutrophil-lymphocyte ratio (NLR), and thrombocyte-lymphocyte ratio (TLR), have been demonstrated in nonsmall cell lung cancer (NSCLC) [10]. In addition, the Glasgow prognostic score, which is a combination of albumin and C-reactive protein (CRP), has also been shown to be a predictive factor for OS and progression-free survival (PFS) in older patients with NSCLC treated with curative CRT [11]. A combination of G8 scores and basic laboratory parameters may cover the essential aspects of both nutritional and clinical characteristics, and provide a better prediction of survival in older patients with NSCLC than the G8 alone. Nevertheless, there is a paucity of studies examining the G8 screening tool and basic laboratory parameters together in older patients with NSCLC. The purpose of this study was to evaluate the role of G8 scores along with basic laboratory parameters in predicting PFS and OS of older patients with NSCLC undergoing radiotherapy.