Inhibition of mammalian target of rapamycin signaling pathway decreases retinoic acid stimulated gene 8 expression in adult mouse testis

Sahin, PINAR; Sahin, Zeliha; GUNGOR-ORDUERI, N.; Donmez, BARIŞ; Celik-Ozenci, ÇİLER

doi:10.1016/j.fertnstert.2014.08.004

Inhibition of mammalian target of rapamycin signaling pathway decreases retinoic acid stimulated gene 8 expression in adult mouse testis

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Sahin P., Sahin Z., GUNGOR-ORDUERI N. E., Donmez B. Ö., Celik-Ozenci C.

FERTILITY AND STERILITY, vol.102, no.5, 2014 (SCI-Expanded)

Publication Type: Article / Article
Volume: 102 Issue: 5
Publication Date: 2014
Doi Number: 10.1016/j.fertnstert.2014.08.004
Journal Name: FERTILITY AND STERILITY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Keywords: mTOR, rapamycin, seminiferous tubule culture, STRA8, MEIOTIC INITIATION, GONADAL-FUNCTION, S6 KINASE, SIROLIMUS, TRANSLATION, EVEROLIMUS, STRA8, MTOR
Akdeniz University Affiliated: Yes

Abstract

Objective: To evaluate the expression of mammalian target of rapamycin (mTOR) pathway molecules in mouse spermatogenesis and as well as its role during proliferation and meiotic initiation of spermatogenic cells.