Atıf İçin Kopyala
Ozenci A. M., Aslan T., Şahin Z., Ozbey O., Acar N., Üstünel İ.
ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA, cilt.47, sa.6, ss.430-435, 2013 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
47
Sayı:
6
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Basım Tarihi:
2013
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Doi Numarası:
10.3944/aott.2013.3136
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Dergi Adı:
ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
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Sayfa Sayıları:
ss.430-435
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Anahtar Kelimeler:
Apoptosis, cartilage, chondrocyte, corticosteroid, zoledronic acid, OSTEOARTHRITIC CARTILAGE, LIVER-TRANSPLANTATION, OSTEOCYTE APOPTOSIS, GROWTH-FACTOR, BONE-CELLS, IN-SITU, BISPHOSPHONATES, RABBIT, MICE, GLUCOCORTICOIDS
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Akdeniz Üniversitesi Adresli:
Evet
Özet
Objective: The aim of this study was to assess the apoptotic effects of systemic corticosteroid application on the articular cartilage chondrocytes in vivo and to investigate the potential effects of zoledronic acid on corticosteroid-induced apoptosis.
Methods: Twenty-four Wistar rats were randomly divided into 3 groups. In the control group, intramuscular isotonic salt solution was injected weekly. In the second group, a dose of 10 mg/kg intramuscular corticosteroid (methylprednisolone) injection was applied weekly for 8 weeks. In the third group, a dose of 10 mg/kg intramuscular corticosteroid (methylprednisolone) injection was applied weekly for 8 weeks and 0.1 mg/kg zoledronic acid was injected subcutaneously on days 0, 21 and 42. Femoral head specimens from each group were obtained at the end of the treatment and the TUNEL method was applied to detect apoptotic chondrocytes. Comparison analyses were performed using the ANOVA method and Tukey’s test.
Results: There was a significant difference between the corticosteroid group and two other groups (control group: p=0.005; corticosteroid + zoledronic acid group: p=0.047). Zoledronic acid treatment significantly decreased the number of corticosteroid-induced apoptotic chondrocytes in the joint cartilage (p<0.05).
Conclusion: Zoledronic acid may have the potential to prevent joint cartilage deterioration due to the corticosteroid-induced apoptosis of the chondrocytes.