Comparison of the beneficial effect of melatonin on recovery after cut and crush sciatic nerve injury: a combined study using functional, electrophysiological, biochemical, and electron microscopic analyses

Kaya, Yasemin; SARIKCIOĞLU, LEVENT; Aslan, Mutay; Kencebay, CEREN; DEMİR, NECDET; DERİN, NARİN; Angelov, Doychin; YILDIRIM, FATOŞ

doi:10.1007/s00381-012-1936-0

Comparison of the beneficial effect of melatonin on recovery after cut and crush sciatic nerve injury: a combined study using functional, electrophysiological, biochemical, and electron microscopic analyses

Kaya Y., SARIKCIOĞLU L., Aslan M., Kencebay C., DEMİR N., DERİN N., ...More

CHILDS NERVOUS SYSTEM, vol.29, no.3, pp.389-401, 2013 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 29 Issue: 3
Publication Date: 2013
Doi Number: 10.1007/s00381-012-1936-0
Journal Name: CHILDS NERVOUS SYSTEM
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.389-401
Keywords: Melatonin, Antioxidant enzymes, Nerve injury, Combined analysis, SOMATOSENSORY-EVOKED-POTENTIALS, SPINAL-CORD-INJURY, OXIDATIVE DAMAGE, RAT-BRAIN, MYOCARDIAL ISCHEMIA/REPERFUSION, ANTIOXIDANT ENZYMES, LOCAL INFLAMMATION, RADICAL SCAVENGER, MOLECULAR DAMAGE, WALKING TRACKS
Akdeniz University Affiliated: Yes

Abstract

Following tissue injury, melatonin is known to reduce detrimental effects of free radicals by stimulating antioxidant enzymes and also to inhibit posttraumatic polymorphonuclear infiltration. Beneficial effects after peripheral nerve injury have been suggested, but not studied in detail. Therefore, we aimed to elucidate the effects of melatonin on the recovery of the lesioned rat sciatic nerve by means of combined analysis.