Comparison of the beneficial effect of melatonin on recovery after cut and crush sciatic nerve injury: a combined study using functional, electrophysiological, biochemical, and electron microscopic analyses

Kaya, Yasemin; SARIKCIOĞLU, LEVENT; Aslan, Mutay; Kencebay, CEREN; DEMİR, NECDET; DERİN, NARİN; Angelov, Doychin; YILDIRIM, FATOŞ

doi:10.1007/s00381-012-1936-0

Comparison of the beneficial effect of melatonin on recovery after cut and crush sciatic nerve injury: a combined study using functional, electrophysiological, biochemical, and electron microscopic analyses

Atıf İçin Kopyala

Kaya Y., SARIKCIOĞLU L., Aslan M., Kencebay C., DEMİR N., DERİN N., ...Daha Fazla

CHILDS NERVOUS SYSTEM, cilt.29, sa.3, ss.389-401, 2013 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 29 Sayı: 3
Basım Tarihi: 2013
Doi Numarası: 10.1007/s00381-012-1936-0
Dergi Adı: CHILDS NERVOUS SYSTEM
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.389-401
Anahtar Kelimeler: Melatonin, Antioxidant enzymes, Nerve injury, Combined analysis, SOMATOSENSORY-EVOKED-POTENTIALS, SPINAL-CORD-INJURY, OXIDATIVE DAMAGE, RAT-BRAIN, MYOCARDIAL ISCHEMIA/REPERFUSION, ANTIOXIDANT ENZYMES, LOCAL INFLAMMATION, RADICAL SCAVENGER, MOLECULAR DAMAGE, WALKING TRACKS
Akdeniz Üniversitesi Adresli: Evet

Özet

Following tissue injury, melatonin is known to reduce detrimental effects of free radicals by stimulating antioxidant enzymes and also to inhibit posttraumatic polymorphonuclear infiltration. Beneficial effects after peripheral nerve injury have been suggested, but not studied in detail. Therefore, we aimed to elucidate the effects of melatonin on the recovery of the lesioned rat sciatic nerve by means of combined analysis.