Akademik Veri Yönetim Sistemi
CLINICAL ORAL INVESTIGATIONS, cilt.27, sa.6, ss.3159-3167, 2023 (SCI-Expanded)
Objectives The present case-control study aims to investigate the salivary levels of bactericidal/permeability-increasing protein (BPI) and interleukin-1beta (IL-1ss) in systemically healthy individuals with periodontitis and periodontally healthy for the evaluation of BPI's relation with periodontal inflammation and clinical diagnosis of periodontitis. Materials and methods A total of 100 participants were enrolled in this study and divided into periodontitis (P group) (n = 50) and periodontally healthy (H group) (n = 50) groups based on their full-mouth periodontal examination results including plaque index, probing pocket depth, gingival index, bleeding on probing, and clinical attachment level. Unstimulated whole saliva was collected. Salivary BPI and IL-1 beta levels were determined using an enzyme-linked immunosorbent assay. Receiver operating characteristic (ROC) curves were created to determine the diagnostic value of BPI. Results The levels of BPI and IL-1ss in saliva were significantly higher in the P group than in the H group (p < 0.001). Moreover, salivary BPI and IL-1ss levels correlated significantly with all clinical periodontal parameters (all p < 0.001). Interestingly, there was a strong positive correlation between salivary levels of BPI and IL-1ss (r=0.544, p < 0.001). In addition, the results of the ROC curve analysis showed that BPI had a high diagnostic potential to distinguish periodontitis from healthy controls with an area under the curve value of 0.94% (p < 0.000). Conclusion The significantly higher salivary levels of BPI in periodontitis patients together with strong positive correlations between all periodontal parameters and salivary IL-1ss levels suggest that BPI may be involved in the inflammatory process of periodontal disease.