Hypoglossal-facial anastomosis (HFA) over a 10 mm gap bridged by a Y-tube-conduit enhances neurite regrowth and reduces collateral axonal branching at the lesion site

ÖZSOY U., DEMİREL B. M., HİZAY A., ÖZSOY Ö., Ankerne J., Angelova S., ...Daha Fazla

RESTORATIVE NEUROLOGY AND NEUROSCIENCE, cilt.29, sa.4, ss.227-242, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 4
  • Basım Tarihi: 2011
  • Doi Numarası: 10.3233/rnn-2011-0594
  • Dergi Adı: RESTORATIVE NEUROLOGY AND NEUROSCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.227-242
  • Anahtar Kelimeler: Motoneuron, nerve repair, facial nerve, hypoglossal nerve, entubulation, functional recovery, PERIPHERAL-NERVE REGENERATION, SELECTIVE REINNERVATION, MUSCLE REINNERVATION, MANUAL STIMULATION, TISSUE-SPECIFICITY, SCHWANN-CELLS, IN-VIVO, RAT, MOTOR, RECOVERY
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Purpose: The outcome of severe peripheral nerve injuries requiring surgical repair (transection and suture) is usually poor. Recent work suggests that direct suture of nerves increases collagen production and provides unfavourable conditions for a proper axonal regrowth. We tested whether entubulation of the hypoglossal nerve into a Y-tube conduit connecting it with the zygomatic and buccal facial nerve branches would improve axonal pathfinding at the lesion site, quality of muscle reinnervation and recovery of vibrissal whisking.