The effects of sulfite on cPLA(2), caspase-3, oxidative stress and locomotor activity in rats

Basaranlar G., DERİN N., MANAS C., TANRIÖVER G., Aslan M.

FOOD AND CHEMICAL TOXICOLOGY, vol.123, pp.453-458, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 123
  • Publication Date: 2019
  • Doi Number: 10.1016/j.fct.2018.11.021
  • Journal Name: FOOD AND CHEMICAL TOXICOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.453-458
  • Keywords: Sulfite, Phospholipase A2, Hippocampus, Locomotor activity, Caspase-3, Antioxidant capacity, VISUAL-EVOKED POTENTIALS, INGESTED SULFITE, LIPID-PEROXIDATION, OXIDASE, ANTIOXIDANT, HIPPOCAMPUS, ANXIETY, ACTIVATION, POLLUTANTS, GENERATION
  • Akdeniz University Affiliated: Yes

Abstract

Sulfite is a commonly used preservative in food products, alcoholic beverages and pharmaceutical products. We investigated the effect of sulfite, on locomotor activity as well as the relationship of these effects with oxidant and antioxidant capacities, cPLA2 enzyme activity. Thirty male Wistar albino rats were randomly divided into two groups as control(C) and sulfite(S). Animals in the S group were given freshly prepared sulfite for 35 days via gastric gavage (100 mg/kg/day) while the C group received equal volumes of distilled water via gavage for the same period. Open-field tests were performed to all groups and animals were sacrificed. Total antioxidant capacity(TAC), TBARS levels, cPLA2 activity as well as amount of caspase-3 positive cells were analyzed on the hippocampi.