Small cell carcinoma of the cervix: a case report

Korcum A. F., Aksu G., Bozcuk H., Pestereli E., ŞİMŞEK T.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS, vol.277, no.4, pp.367-370, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 277 Issue: 4
  • Publication Date: 2008
  • Doi Number: 10.1007/s00404-007-0463-9
  • Journal Name: ARCHIVES OF GYNECOLOGY AND OBSTETRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.367-370
  • Keywords: uterine cervix, small cell carcinoma, combined modality treatment, NEUROENDOCRINE CARCINOMA, HUMAN-PAPILLOMAVIRUS, PROGNOSTIC-FACTORS, UTERINE CERVIX, CISPLATIN, DOXORUBICIN, CYCLOPHOSPHAMIDE, VINCRISTINE, ALTERNATION, EXPRESSION
  • Akdeniz University Affiliated: Yes

Abstract

Small cell carcinoma of the uterine cervix accounts for 1-3% of all cervix cancers. It is an aggressive disease with a poor prognosis. To date, no effective treatment protocol has been determined. Surgery, radiotherapy, and chemotherapy have been used either alone or in combination. Recent data suggests that survival in patients with early staged small cell carcinoma of the cervix is better with surgery combined with chemo-radiotherapy. Here, we presented two patients with stage IB1 small cell carcinoma of the uterine cervix. For both patients, definitive surgery was performed with pelvic and para-aortic lymphadenectomy. Subsequently, they were treated with pelvic external radiotherapy and high-dose-rate intracavitary brachytherapy with concurrent cisplatin based chemotherapy. They were alive with no evidence of disease at 91 and 65 months, respectively.