Bioactivity studies of algal extracts from Turkey's Mediterranean coast
PLANTA MEDICA, cilt.82, sa.S 01, ss.381, 2016 (SCI-Expanded)
- Yayın Türü: Makale / Özet
- Cilt numarası: 82 Sayı: S 01
- Basım Tarihi: 2016
- Dergi Adı: PLANTA MEDICA
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.381
- Akdeniz Üniversitesi Adresli: Evet
Özet
Turkey is a country of peninsula with nearly 8300 km marine coasts and the rich biodiversity of this region, however, has not been investigated completely from the view point of biological active extracts [1]. In this study, eight different marine algae distributed in Hatay, Mediterranean Coasts, were investigated for their superoxide (SO) radical scavenging effects and cytotoxic activities against Hep-2 (Human Epidermoid Carcinoma) cancer cell line. SO radical scavenging activity was tested in the concentration range of 100 – 800 µg/mL. While Liagora viscida and Padina sp. (IC50 > 800 µg/mL) extracts showed dose dependent SO radical scavenging activity but lower than that of ascorbic acid and quercetin, other tested extracts did not show any activity in tested concentrations. On the other hand, cytotoxic activity of the extracts was tested by MTT method and methanoic extracts of Padina sp., Liagora viscida and Laurencia obtusa (IC50 < 10 µg/mL) showed dose dependent and significant cytotoxic activity. However, methanolic extracts of Dictyota dichotoma, Hypnea musciformis, Codium fragile, Palisada perforata and Gracilaria bursa-pastoris (IC50: 10 – 100 µg/mL) showed moderate cytotoxicity. Based on the bioactivities of the methanolic extract of Padina sp. and Liagora viscida, phytochemical studies will be initiated to find the active components in the extracts of these species.