Alteration of cholinergic presser and antinociceptive responses in rats pretreated with the cholinergic toxin AF64A

Tellioglu T., Erin N., Akin S. B., Berkman K., Oktay Ş.

General Pharmacology, vol.30, no.4, pp.525-531, 1998 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 4
  • Publication Date: 1998
  • Doi Number: 10.1016/s0306-3623(97)00298-x
  • Journal Name: General Pharmacology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.525-531
  • Keywords: AF64A, Alzheimer's disease, Antinociception, Blood pressure, Cholinergic control, Oxotremorine, Physostigmine
  • Akdeniz University Affiliated: No

Abstract

1. In the present study, the pressor and antinociceptive effects of physostigmine and oxotremorine were investigated in rats injected with AF64A intracerebroventricularly. 2. Physostigmine (50-100 μg/kg, IV)-induced pressor responses were significantly lower in AF64A-injected rats compared with saline injected animals, whereas oxotremorine (20-80 μg/kg, IV)-induced responses were found to be similar to those seen in the saline group. 3. The physostigmine (100 μg/kg, SC)-induced antinociceptive effect was totally abolished by AF64A treatment, but that of oxotremorine (30 μg/kg, SC) remained unchanged at the tail-flick test. 4. The results of this study present functional evidence for AF64A-produced substantial loss of cholinergic neurons involved in the regulation of blood pressure and nociception but not in postsynaptic muscarinic receptors.