The importance of stromal and intratumoral tumor lymphocyte infiltration for pathologic complete response in patients with locally advanced breast cancer

Eryilmaz M. K., Mutlu H., ÜNAL B., Salim D. K., Musri F. Y., COŞKUN H. Ş.

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, cilt.14, sa.3, ss.619-624, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.4103/0973-1482.174550
  • Dergi Adı: JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.619-624
  • Anahtar Kelimeler: Breast cancer, neoadjuvant chemotherapy, pathologic complete response, tumor-infiltrating lymphocytes, SURGICAL ADJUVANT BREAST, PROGNOSTIC-SIGNIFICANCE, NEOADJUVANT CHEMOTHERAPY, FOXP3 EXPRESSION, PREDICTIVE-VALUE, FREE SURVIVAL, TRASTUZUMAB, CELLS, ASSOCIATION, DOXORUBICIN
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Objective: Increased tumor-infiltrating lymphocytes (TILs) in breast carcinoma tissues is an independent predictive factor for pathologic complete response (pCR). The increased intratumoral and stromal TILs (sTILs) in breast cancer (BC) have significant prognostic effects. In this study, we evaluated whether pCR rates to neoadjuvant chemotherapy (NACT) are higher in tumors with increased number of TILs in the pretreatment biopsy.