Akademik Veri Yönetim Sistemi
III. International Kayseri Scientific Research Conference, Kayseri, Türkiye, 20 - 21 Temmuz 2024, ss.165
Bordetella bronchiseptica is known as a bacterium that typically causes respiratory tract
infections in animals. However, it can also rarely cause infections in humans. Infections with
this bacterium in humans usually show mild symptoms that resemble the symptoms of a
respiratory infection symptoms such as cough, runny nose, sore throat, and fever. In rare cases,
especially in individuals with immunodeficiency, it can cause severe lower respiratory tract
infections such as pneumonia. It is important to understand the impact of this bacterium on
human health and to link it to with clinical findings. In this study, 16S rRNA analysis and
MALDI-TOF analysis were performed on a clinical isolate thought to be Bordetella pertussis,
and the bacterium was identified as B. bronchiseptica. Additionally, the resistance profile was
analysed for macrolide antibiotics commonly used in the clinical setting for Bordetella
infections (azithromycin, clarithromycin, erythromycin), as well as alternative antibiotics used
in patients with macrolide intolerance, such as trimethoprim-sulfamethoxazole, and other
antibiotics (kanamycin, tetracycline, ampicillin, imipenem, chloramphenicol). The results
confirmed that the isolate belonged to B. bronchiseptica and indicated the presence of antibiotic
resistance. There is currently insufficient research in the literature on antibiotic resistance in
Bordetella overall, and there are not internationally recognised standards for Bordetella
detection methods or the results of various antibiotic resistance tests. In this study, B.
bronchiseptica was found to be resistant to trimethoprim-sulfamethoxazole and ampicillin as
no inhibition zone was observed for these antibiotics. The biggest inhibition zones for the
isolate were observed with the antibiotics imipenem, azithromycin, and clarithromycin. The
sensitivity to other antibiotics was found to be very low. The impact of B. bronchiseptica on
human health and its clinical manifestations require further investigation. In particular, a better
understanding of the epidemiology and transmission mechanisms of the infections is needed to
develop more effective diagnostic and treatment strategies.