Effects of high-dose intravenous immunoglobulin on lipopolysaccharide-induced acute lung injury

OYGUCU S. E., ÖZBUDAK İ. H., AKCAN A. B., COŞKUN M., Ozel D., ÖZBİLİM G., ...More

INTERNATIONAL IMMUNOPHARMACOLOGY, vol.21, no.1, pp.51-55, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 1
  • Publication Date: 2014
  • Doi Number: 10.1016/j.intimp.2014.04.002
  • Journal Name: INTERNATIONAL IMMUNOPHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.51-55
  • Keywords: Acute lung injury, Immunoglobulin, Transforming growth factor beta (TGF-beta), Inflammation, TUMOR-NECROSIS-FACTOR, GROWTH-FACTOR-BETA, RESPIRATORY-DISTRESS-SYNDROME, PULMONARY-FIBROSIS, RAT MODEL, TGF-BETA, INFLAMMATORY RESPONSE, MONOCLONAL-ANTIBODY, CONTROLLED-TRIAL, IMMUNE GLOBULIN
  • Akdeniz University Affiliated: Yes

Abstract

Purpose: Intravenous immunoglobulin (IVIG) therapy is used in inflammatory diseases but the use of immunoglobulin as a treatment for acute lung injury (ALI) has not been previously studied. Transforming growth factor beta (TGF-beta) plays a critical role in the pathogenesis of of ALI. Therefore we examined the levels of TGF-beta and lung inflammation scores in WIG treated ALI models.