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OYGUCU S. E., ÖZBUDAK İ. H., AKCAN A. B., COŞKUN M., Ozel D., ÖZBİLİM G., ...More
INTERNATIONAL IMMUNOPHARMACOLOGY, vol.21, no.1, pp.51-55, 2014 (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
21
Issue:
1
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Publication Date:
2014
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Doi Number:
10.1016/j.intimp.2014.04.002
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Journal Name:
INTERNATIONAL IMMUNOPHARMACOLOGY
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Page Numbers:
pp.51-55
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Keywords:
Acute lung injury, Immunoglobulin, Transforming growth factor beta (TGF-beta), Inflammation, TUMOR-NECROSIS-FACTOR, GROWTH-FACTOR-BETA, RESPIRATORY-DISTRESS-SYNDROME, PULMONARY-FIBROSIS, RAT MODEL, TGF-BETA, INFLAMMATORY RESPONSE, MONOCLONAL-ANTIBODY, CONTROLLED-TRIAL, IMMUNE GLOBULIN
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Akdeniz University Affiliated:
Yes
Abstract
Purpose: Intravenous immunoglobulin (IVIG) therapy is used in inflammatory diseases but the use of immunoglobulin as a treatment for acute lung injury (ALI) has not been previously studied. Transforming growth factor beta (TGF-beta) plays a critical role in the pathogenesis of of ALI. Therefore we examined the levels of TGF-beta and lung inflammation scores in WIG treated ALI models.