Research Information System
JAREM, vol.11, no.2, pp.143-148, 2021 (Peer-Reviewed Journal)
Objective: This study aimed to assess the relationship of 25-hydroxyvitamin D [25(OH)D] levels at presentation with the clinical, laboratory and followup data of children and adolescents with type-1 diabetes mellitus. Methods: Patients who had available follow-up data and were diagnosed to have type-1 diabetes mellitus in our clinic between 2009 and 2015 were included. Patient files were screened for data regarding presentation, history/family history and clinical, laboratory and follow-up data. Data were also assessed in the context of threshold values for sufficiency, insufficiency or deficiency of 25(OH)D. Results: The mean age was 8.62±14.19 years. Type-1 diabetes mellitus was diagnosed as diabetic ketoacidosis in 53.9% of the patients. The mean 25(OH)D level was 18.90±11.07 ng/mL at the time of diagnosis. The mean time to subcutaneous insulin therapy through the resolution of ketosis/ diabetic ketoacidosis in the group with vitamin D deficiency was significantly longer than vitamin D insufficient and sufficient groups (p=0.020). The mean 25(OH)D levels were lower in patients diagnosed with moderate and severe diabetic ketoacidosis (p=0.020). Insulin doses at discharge were significantly lower in patients with a mean 25(OH)D level of 10-20 ng/mL (p=0.039). The relationship of vitamin D groups with HbA1c and insulin doses in the follow-up period was not significant. Conclusion: This pilot study assessed the clinical, laboratory and follow-up data and the honeymoon status on month 2 (±1). We found that 25(OH)D levels affected clinical features at the time of diagnosis but not during follow-up.