Quick assessment of cell-free DNA in seminal fluid and fragment size for early non-invasive prostate cancer diagnosis

Ponti, Giovanni; Maccaferri, Monia; Manfredini, Marco; Micali, Salvatore; Torricelli, Federica; Milandri, Riccardo; del Prete, Chiara; Ciarrocchi, Alessia; Ruini, Cristel; Benassi, Luisa; Bettelli, Stefania; Kaleci, Shaniko; Ozben, TOMRİS; Tomasi, Aldo

doi:10.1016/j.cca.2019.07.011

Quick assessment of cell-free DNA in seminal fluid and fragment size for early non-invasive prostate cancer diagnosis

Ponti G., Maccaferri M., Manfredini M., Micali S., Torricelli F., Milandri R., ...More

CLINICA CHIMICA ACTA, vol.497, pp.76-80, 2019 (SCI-Expanded)

Publication Type: Article / Article
Volume: 497
Publication Date: 2019
Doi Number: 10.1016/j.cca.2019.07.011
Journal Name: CLINICA CHIMICA ACTA
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.76-80
Keywords: Seminal cell-free DNA, cfDNA fragment size distribution, Non-invasive prostate cancer diagnosis, Benign prostatic hyperplasia, CIRCULATING DNA, QUANTIFICATION, TUMOR
Open Archive Collection: AVESIS Open Access Collection
Akdeniz University Affiliated: Yes

Abstract

Background: Liquid biopsy consists in the quantification and qualification of circulating cell-free DNA (cfDNA) and tumor-derived DNA (ctDNA) for cancer recognition. Recently, the characterization of seminal cfDNA (scfDNA) has been reported as a possible biomarker for prostate cancer (PCa) diagnosis.