Detection of Pulmonary Embolism with Gallium-68 Macroaggregated Albumin Perfusion PET/CT: An Experimental Study in Rabbits

Creative Commons License

GÜLTEKİN A., Cayir M. C., Ugur A., Bir F., YÜKSEL D.

CONTRAST MEDIA & MOLECULAR IMAGING, cilt.2020, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 2020
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1155/2020/5607951
  • Dergi Adı: CONTRAST MEDIA & MOLECULAR IMAGING
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, INSPEC, MEDLINE, Directory of Open Access Journals
  • Akdeniz Üniversitesi Adresli: Evet

Özet

This study was designed to evaluate the accuracy of detecting pulmonary embolism (PE) using the Technegas SPECT/CT combined with Ga-68 PET/CT in a rabbit model. One hour after artificial PE (n = 6) and sham (n = 6) models were created, Technegas SPECT/CT ventilation and Ga-68-MAA PET/CT perfusion scan (V/Q scan) were performed. Ventilation imaging was performed first on all cases. Technegas SPECT/CT and Ga-68-MAA PET/CT images were evaluated by a nuclear medicine physician who recorded the presence, number, and location of PE on a per-lobe basis. The sensitivity, specificity, and accuracy of Technegas SPECT/CT and Ga-68-MAA PET/CT for detecting PE were calculated using a histopathological evaluation as a reference standard. A total of 60 lung lobes were evaluated in 12 rabbits, and PE was detected in 20 lobes in V/Q scans and histopathological analysis. The overall sensitivity, specificity, and accuracy were 100%, 100%, and 100%, respectively, for both the Technegas SPECT/CT and Ga-68-MAA PET/CT V/Q scans. Technegas/Ga-68-MAA V/Q scans have good sensitivity, specificity, and accuracy in the detection of PE in this animal model study.