Antiseizure activity of insulin: Insulin inhibits pentylenetetrazole, penicillin and kainic acid-induced seizures in rats

UYSAL H., Kuli P., Caglar S., Inan L., Akarsu E., Palaoglu O., ...Daha Fazla

EPILEPSY RESEARCH, cilt.25, sa.3, ss.185-190, 1996 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 3
  • Basım Tarihi: 1996
  • Doi Numarası: 10.1016/s0920-1211(96)00078-2
  • Dergi Adı: EPILEPSY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.185-190
  • Anahtar Kelimeler: insulin, seizure, pentylenetetrazole, penicillin, kainic acid, ouabain, rat, BRAIN, TRANSPORT, RECEPTORS
  • Akdeniz Üniversitesi Adresli: Hayır

Özet

The present study was undertaken to evaluate the antiseizure activity spectrum of insulin against various behavioral seizure models in rats. Insulin was injected intraperitoneally (i.p.) at a test dose of 1 U/kg. Dextrose (3 g/kg) was administered simultaneously with insulin to counteract its hypoglycemic effect and induce a normoglycemic state. Insulin was found to significantly decrease the incidence, intensity and mortality rate and prolong the latency of generalized tonic-clonic convulsions induced by pentylenetetrazole (60 mg/kg i.p.) and significantly decrease the intensity and mortality rate and prolong the latency of generalized tonic-clonic convulsions induced by penicillin (2000 U/intracerebrocoaical). Insulin was not only found to prolong the latency of all the seizure components but was found to reduce the incidence of focal myoclonic twitches and generalized tonic-clonic convulsions induced by kainic acid (12 mg/kg i.p.) as well. Insulin was shown to be ineffective to suppress ouabain (5 mu g/intracerebroventricular) induced seizures. These findings indicate that insulin possesses a broad spectrum of antiseizure activity in rats. Interaction with brain Na+-K+-ATPase has been discussed as a possible mechanism of action.