The prognostic relevance of angiogenesis and mast cells in squamous cell carcinoma of the oesophagus

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ELPEK G. Ö., gelen t., AKSOY N., Erdogan A., DERTSİZ L., demircan a., ...Daha Fazla

JOURNAL OF CLINICAL PATHOLOGY, cilt.54, sa.12, ss.940-944, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54 Sayı: 12
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1136/jcp.54.12.940
  • Dergi Adı: JOURNAL OF CLINICAL PATHOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.940-944
  • Anahtar Kelimeler: microvessel density, mast cell, prognosis, oesophagus, squamous cell carcinoma, angiogenesis, MESSENGER-RNA EXPRESSION, CORRECTED MITOTIC INDEX, TUMOR ANGIOGENESIS, GROWTH-FACTOR, MICROVESSEL DENSITY, THYMIDINE PHOSPHORYLASE, BREAST-CANCER, PROLIFERATION, ESOPHAGUS, VOLUME
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Aims-Angiogenesis, an important prognostic factor in several tumours, is a complex event mediated by angiogenic factors released from cancer cells and host immune cells. Among the host immune cells, a role has been implicated for mast cells in tumour progression via promoting angiogenesis. Data have been recorded that indicate a correlation between intratumoral neovascularisation, as assessed by microvessel density (MVD), and prognosis in squamous cell carcinoma (SCC) of the oesophagus. However, a correlation between mast cell density (MCD) and either prognosis or angiogenesis has not been delineated yet in this disease. The aim of this study was to investigate the prognostic value of MVD and MCD in SCC of the oesophagus. The correlation between MVD and MCD was also evaluated.