Mass Spectrometric Identification of Collagen Alpha-1 (III) Chain and Chondroitin Sulfate Proteoglycan-4 Nitration in Patients with Acute Pulmonary Embolism

ÖZTÜRK O., Eken C., AVCİL Z., Ozcan F., Aslan M.

CURRENT PROTEOMICS, cilt.15, sa.1, ss.34-41, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2174/1570164614666170623102254
  • Dergi Adı: CURRENT PROTEOMICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.34-41
  • Anahtar Kelimeler: Pulmonary embolism, nitrotyrosine, human collagen alpha-1 (III) chain, human chondroitin sulfate proteoglycan 4, spectrometric identification, mass spectrometric, RESPIRATORY-DISTRESS-SYNDROME, VENOUS THROMBOEMBOLISM, LUNG INJURY, PROTEIN, NITROTYROSINE, INFLAMMATION, MANAGEMENT, MARKERS
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: Pulmonary embolism ( PE) is a cardiovascular emergency that affects many patients. Acute PE-induced oxidative stress can lead to the accumulation of nitroproteins that may play a role in disease progression. The impact of nitration of a single tyrosine residue often has broad implications on the activity of biologically critical proteins, related to pathological conditions.