Voriconazole Induced Bradycardia
PEDIATRIC HEMATOLOGY AND ONCOLOGY, vol.30, no.7, pp.674-676, 2013 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 30 Issue: 7
- Publication Date: 2013
- Doi Number: 10.3109/08880018.2013.775616
- Journal Name: PEDIATRIC HEMATOLOGY AND ONCOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.674-676
- Keywords: acute leukemias, clinical microbiology, infectious diseases, pediatrics, INVASIVE FUNGAL-INFECTIONS, CHILDREN
- Akdeniz University Affiliated: No
Abstract
Voriconazole is a triazole antifungal drug that is used to treat invasive fungal infections, especially aspergillus. Here, we report two children who had severe bradycardia associated with voriconazole at a dose of 12 mg/kg per day. Bradycardia resolved in 24 hours in both after decreasing the dose to 10 mg/kg per day. Heart rates were in normal limits on follow-up. Bradycardia may be a side effect of voriconazole treatment in children under immunosuppressive treatment. Heart rate should be monitored in patients receiving voriconazole and other triazole treatments.