Protective effect of nimesulide against hepatic ischemia/reperfusion injury in rats: Effects on oxidant/antioxidants, DNA mutation and COX-1/COX-2 levels

Demiryilmaz, Ismail; TURAN, Mehmet; Kisaoglu, ABDULLAH; GÜLABOĞLU, Mine; Yilmaz, Ismayil; Suleyman, Halis

doi:10.1016/j.pharep.2014.02.015

Protective effect of nimesulide against hepatic ischemia/reperfusion injury in rats: Effects on oxidant/antioxidants, DNA mutation and COX-1/COX-2 levels

Atıf İçin Kopyala

Demiryilmaz I., TURAN M. I., Kisaoglu A., GÜLABOĞLU M., Yilmaz I., Suleyman H.

PHARMACOLOGICAL REPORTS, cilt.66, sa.4, ss.647-652, 2014 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 66 Sayı: 4
Basım Tarihi: 2014
Doi Numarası: 10.1016/j.pharep.2014.02.015
Dergi Adı: PHARMACOLOGICAL REPORTS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.647-652
Anahtar Kelimeler: Rat, Liver, Oxidant/antioxidant, Nimesulide, ISCHEMIA-REPERFUSION INJURY, LIPID-PEROXIDATION, OXIDATIVE STRESS, VITAMIN-C, ELECTROCHEMICAL DETECTION, FREE-RADICALS, DAMAGE, LIVER, ACID, CYCLOOXYGENASE-2
Akdeniz Üniversitesi Adresli: Hayır

Özet

Background: Nimesulide is a pharmacological agent and selective COX-2 inhibitor. It has anti-inflammatory, analgesic and antipyretic properties. The purpose of this study was to investigate the effect of nimesulide on oxidant/antioxidant, DNA mutation and COX-1/COX-2 activities in rat liver tissue with induced ischemia/reperfusion (I/R).