Protective effect of nimesulide against hepatic ischemia/reperfusion injury in rats: Effects on oxidant/antioxidants, DNA mutation and COX-1/COX-2 levels

Demiryilmaz, Ismail; TURAN, Mehmet; Kisaoglu, ABDULLAH; GÜLABOĞLU, Mine; Yilmaz, Ismayil; Suleyman, Halis

doi:10.1016/j.pharep.2014.02.015

Protective effect of nimesulide against hepatic ischemia/reperfusion injury in rats: Effects on oxidant/antioxidants, DNA mutation and COX-1/COX-2 levels

Demiryilmaz I., TURAN M. I., Kisaoglu A., GÜLABOĞLU M., Yilmaz I., Suleyman H.

PHARMACOLOGICAL REPORTS, vol.66, no.4, pp.647-652, 2014 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 66 Issue: 4
Publication Date: 2014
Doi Number: 10.1016/j.pharep.2014.02.015
Journal Name: PHARMACOLOGICAL REPORTS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.647-652
Keywords: Rat, Liver, Oxidant/antioxidant, Nimesulide, ISCHEMIA-REPERFUSION INJURY, LIPID-PEROXIDATION, OXIDATIVE STRESS, VITAMIN-C, ELECTROCHEMICAL DETECTION, FREE-RADICALS, DAMAGE, LIVER, ACID, CYCLOOXYGENASE-2
Akdeniz University Affiliated: No

Abstract

Background: Nimesulide is a pharmacological agent and selective COX-2 inhibitor. It has anti-inflammatory, analgesic and antipyretic properties. The purpose of this study was to investigate the effect of nimesulide on oxidant/antioxidant, DNA mutation and COX-1/COX-2 activities in rat liver tissue with induced ischemia/reperfusion (I/R).