A pilot study investigating early postoperative changes of plasma polyunsaturated fatty acids after laparoscopic sleeve gastrectomy

Creative Commons License

Aslan M., Aslan I., Ozcan F., Eryilmaz R., Ensari C. O., Bilecik T.

LIPIDS IN HEALTH AND DISEASE, vol.13, 2014 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 13
  • Publication Date: 2014
  • Doi Number: 10.1186/1476-511x-13-62
  • Journal Name: LIPIDS IN HEALTH AND DISEASE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Laparoscopic sleeve gastrectomy, Polyunsaturated fatty acids, Insulin, Prostaglandin, INSULIN-RESISTANCE, DIABETIC-PATIENTS, ARACHIDONIC-ACID, OMEGA-3-FATTY-ACIDS, OMEGA-6, OBESITY, DELTA-6
  • Open Archive Collection: AVESIS Open Access Collection
  • Akdeniz University Affiliated: Yes

Abstract

2014 Apr 3;13(1):62. doi: 10.1186/1476-511X-13-62.

A pilot study investigating early postoperative changes of plasma polyunsaturated fatty acids after laparoscopic sleeve gastrectomy.

Aslan M1, Aslan I, Ozcan F, Eryılmaz R, Ensari CO, Bilecik T.

 

 

Abstract

BACKGROUND:

This study aimed to determine early postoperative changes of plasma polyunsaturated fatty acids (PUFAs) following laparoscopic sleeve gastrectomy (LSG).

METHODS:

Ten obese patients (mean BMI: 51.10 ± 11.59 kg/m2) underwent LSG and eleven normal weight control patients (mean BMI: 24.37 ± 2.33 kg/m2) underwent laparoscopic abdominal surgery. Fasting blood samples were collected prior to surgery, at day 1 after surgery and after postoperation oral feeding. Plasma levels of arachidonic acid (AA, C20:4n6), dihomo-gamma-linolenic acid (DGLA, C20:3n6), eicosapentaenoic acid (EPA, C20:5n3) and docosahexaenoic acid (DHA, C22:6n3) were determined by an optimized multiple reaction monitoring (MRM) method using ultra fast-liquid chromatography (UFLC) coupled with tandem mass spectrometry (MS/MS). Prostaglandin E2 (PGE2) was measured in serum samples by enzyme immunoassay.

RESULTS:

A significant decrease was observed in insulin and HOMA IR levels in sleeve gastrectomy patients after postoperation oral feeding compared to preoperation. Plasma AA levels and AA/EPA ratio were significantly increased in sleeve gastrectomy patients after postoperation oral feeding compared to postoperation day 1. Serum PGE2 levels and AA/DHA ratio was significantly higher in sleeve gastrectomy patients at preoperation, postoperation day 1 and after postoperation oral feeding when compared to control group patients.

CONCLUSION:

Increased peripheral insulin sensitivity associated with LSG may play a role in the significant increase of plasma AA levels in sleeve gastrectomy patients following postoperation oral feeding. The significant increase in PGE2 levels and AA/DHA ratio in sleeve gastrectomy group patients also confirms the presence of a proinflammatory state in obesity.