A pilot study investigating early postoperative changes of plasma polyunsaturated fatty acids after laparoscopic sleeve gastrectomy

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Aslan M., Aslan I., Ozcan F., Eryilmaz R., Ensari C. O., Bilecik T.

LIPIDS IN HEALTH AND DISEASE, cilt.13, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1186/1476-511x-13-62
  • Dergi Adı: LIPIDS IN HEALTH AND DISEASE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Laparoscopic sleeve gastrectomy, Polyunsaturated fatty acids, Insulin, Prostaglandin, INSULIN-RESISTANCE, DIABETIC-PATIENTS, ARACHIDONIC-ACID, OMEGA-3-FATTY-ACIDS, OMEGA-6, OBESITY, DELTA-6
  • Akdeniz Üniversitesi Adresli: Evet

Özet

2014 Apr 3;13(1):62. doi: 10.1186/1476-511X-13-62.

A pilot study investigating early postoperative changes of plasma polyunsaturated fatty acids after laparoscopic sleeve gastrectomy.

Aslan M1, Aslan I, Ozcan F, Eryılmaz R, Ensari CO, Bilecik T.

 

 

Abstract

BACKGROUND:

This study aimed to determine early postoperative changes of plasma polyunsaturated fatty acids (PUFAs) following laparoscopic sleeve gastrectomy (LSG).

METHODS:

Ten obese patients (mean BMI: 51.10 ± 11.59 kg/m2) underwent LSG and eleven normal weight control patients (mean BMI: 24.37 ± 2.33 kg/m2) underwent laparoscopic abdominal surgery. Fasting blood samples were collected prior to surgery, at day 1 after surgery and after postoperation oral feeding. Plasma levels of arachidonic acid (AA, C20:4n6), dihomo-gamma-linolenic acid (DGLA, C20:3n6), eicosapentaenoic acid (EPA, C20:5n3) and docosahexaenoic acid (DHA, C22:6n3) were determined by an optimized multiple reaction monitoring (MRM) method using ultra fast-liquid chromatography (UFLC) coupled with tandem mass spectrometry (MS/MS). Prostaglandin E2 (PGE2) was measured in serum samples by enzyme immunoassay.

RESULTS:

A significant decrease was observed in insulin and HOMA IR levels in sleeve gastrectomy patients after postoperation oral feeding compared to preoperation. Plasma AA levels and AA/EPA ratio were significantly increased in sleeve gastrectomy patients after postoperation oral feeding compared to postoperation day 1. Serum PGE2 levels and AA/DHA ratio was significantly higher in sleeve gastrectomy patients at preoperation, postoperation day 1 and after postoperation oral feeding when compared to control group patients.

CONCLUSION:

Increased peripheral insulin sensitivity associated with LSG may play a role in the significant increase of plasma AA levels in sleeve gastrectomy patients following postoperation oral feeding. The significant increase in PGE2 levels and AA/DHA ratio in sleeve gastrectomy group patients also confirms the presence of a proinflammatory state in obesity.