Acceleration of Distraction Osteogenesis With Drug-Releasing Distractor

KONAŞ, ERSOY; MAVİLİ, MEHMET; KORKUSUZ, PETEK; Demir, DEVRİM; Oner, Filiz; Canter, Halil

doi:10.1097/scs.0b013e3181be8754

Acceleration of Distraction Osteogenesis With Drug-Releasing Distractor

KONAŞ E., MAVİLİ M. E., KORKUSUZ P., Demir D., Oner F., Canter H. I.

JOURNAL OF CRANIOFACIAL SURGERY, vol.20, no.6, pp.2041-2048, 2009 (SCI-Expanded)

Publication Type: Article / Article
Volume: 20 Issue: 6
Publication Date: 2009
Doi Number: 10.1097/scs.0b013e3181be8754
Journal Name: JOURNAL OF CRANIOFACIAL SURGERY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.2041-2048
Keywords: Distraction osteogenesis, BMP, chitosan, controlled drug release, drug-releasing distractor, BONE MORPHOGENETIC PROTEIN-2, GRADUAL DISTRACTION, RABBIT MODEL, STERILIZATION, DELIVERY, RHBMP-2, RATES, OXIDE
Akdeniz University Affiliated: No

Abstract

Objective: The aim of this study was to develop an internal distractor to release a drug to the distraction site during the distraction process and to investigate whether intermittent bone morphogenetic protein 2 (BMP-2)-containing chitosan hydrogel infusion will improve radiologic and histologic parameters of distraction osteogenesis (DO) when compared with control groups.