Purpose: This article presents the planned protocol for a study that investigates the effects of nursing care interventions based on Integrative Nursing (IN) and the Omaha System. The Omaha System is a nursing classification system focused on holistic care and used in determining nursing diagnoses and applying and evaluating interventions. Design: This study protocol describes a randomized controlled trial with a parallel group design. Method: Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) Statement 2013 checklist is used in this study. The CONSORT (Consolidated Standards of Reporting Trials) flowchart is used in this protocol. After the level of loneliness of older women is determined by the Loneliness Scale for the Elderly in a family health center, women with high levels of loneliness will be randomly assigned to the intervention and control groups. Nursing care interventions consist of group-based (sightseeing, picnics, theater, cinema, group education, and charity activities) and person-centered interventions, according to IN and the Omaha System, for 12 weeks. Conclusions: This protocol will test the effectiveness of nursing care interventions that include a comprehensive (physical, psychological, social, and spiritual) evaluation. The results will help contribute to the provision of care in terms of IN and the Omaha System and guide health professionals and researchers.