In vitro interferon gamma improves the oxidative burst activity of neutrophils in patients with chronic granulomatous disease with a subtype of gp91phox deficiency

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Filiz S., Uygun D. F., KÖKSOY S., Sahin E., Yedin O.

Central European Journal of Immunology, vol.40, no.1, pp.54-60, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.5114/ceji.2015.50833
  • Journal Name: Central European Journal of Immunology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.54-60
  • Keywords: neutrophils, monocytes, interferon gamma, chronic granulomatous disease, GENE-EXPRESSION, CYBB GENE, TRANSCRIPTS, INFECTIONS, MUTATION, THERAPY, VARIANT
  • Akdeniz University Affiliated: Yes

Abstract

Aim of this study: Chronic granulomatous disease (CGD) is a genetically heterogeneous primary immunodeficiency caused by a defect in phagocyte production of oxygen metabolites, and resulting in infections produced by catalase-positive microorganisms and fungi. Inteiferon gamma (IFN-gamma) has a multitude of effects on the immune system. Although preliminary studies with CGD patients on treatment with IFN-gamma showed that it enhanced phagocytosis and superoxide production, ongoing studies did not reveal a significant increase of this function. Here we investigated the oxidative capacity of phagocytes in different subtypes of CGD patients on treatment with IFN-gamma in vitro.