In vitro interferon gamma improves the oxidative burst activity of neutrophils in patients with chronic granulomatous disease with a subtype of gp91phox deficiency
Central European Journal of Immunology, cilt.40, sa.1, ss.54-60, 2015 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 40 Sayı: 1
- Basım Tarihi: 2015
- Doi Numarası: 10.5114/ceji.2015.50833
- Dergi Adı: Central European Journal of Immunology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.54-60
- Anahtar Kelimeler: neutrophils, monocytes, interferon gamma, chronic granulomatous disease, GENE-EXPRESSION, CYBB GENE, TRANSCRIPTS, INFECTIONS, MUTATION, THERAPY, VARIANT
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Akdeniz Üniversitesi Adresli: Evet
Özet
Aim of this study: Chronic granulomatous disease (CGD) is a genetically heterogeneous primary immunodeficiency caused by a defect in phagocyte production of oxygen metabolites, and resulting in infections produced by catalase-positive microorganisms and fungi. Inteiferon gamma (IFN-gamma) has a multitude of effects on the immune system. Although preliminary studies with CGD patients on treatment with IFN-gamma showed that it enhanced phagocytosis and superoxide production, ongoing studies did not reveal a significant increase of this function. Here we investigated the oxidative capacity of phagocytes in different subtypes of CGD patients on treatment with IFN-gamma in vitro.