Journal of Prosthodontics, 2025 (SCI-Expanded)
Purpose: To investigate the effects of occlusal finish line, material, cement, and aging type on the microleakage and fracture strength of inlay restorations in vitro. Materials and Methods: Mesio-occluso-distal (MOD) inlay cavities were prepared in all teeth with an occlusal finish line in the form of a butt joint (BJ) or hollow-ground chamfer (HC) in one wall (buccal) (n = 80 each). Inlay restorations were designed using a computer-aided design and computer-aided manufacturing (CAD-CAM) device and milled from blocks (lithium disilicate ceramic [IPS e.max CAD] [LD] and resin nanoceramic [Lava Ultimate] [RN] [n = 40 each]). Inlay restorations were cemented to each tooth with dual-cure resin cement (RelyX Ultimate) (RU) or dual-cure self-adhesive resin cement (RelyX U200) (RU2) (n = 20 each). Specimens were divided into two groups (control [C] and thermomechanical aging [TM]) (n = 10 each). Microleakage and fracture strength tests were performed. The failure types were determined. Microleakage data (mm3) and fracture strength data (N) were analyzed by 4-way analysis of variance (ANOVA). Pairwise comparisons were made by Bonferroni testing. Fisher–Freeman–Halton testing was used to examine the relationship between categorical data. The correlation between microleakage and fracture strength was analyzed using Pearson's correlation analysis (p = 0.05). Results: Although the occlusal finish line, cement, and aging type affected the microleakage (p < 0.001), only the occlusal finish line type affected the fracture strength (p = 0.007). Relationships between the microleakage and fracture strength data were nonsignificant in all subgroups. Conclusions: For inlay restorations, an HC finish line and RU resin cement can be recommended.