Synaptosomal-associated protein 25 (Snap-25) gene Polymorphism frequency in fibromyalgia syndrome and relationship with clinical symptoms

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Balkarli A., Sengul C., Tepeli E., Balkarli H., Cobankara V.

BMC MUSCULOSKELETAL DISORDERS, vol.15, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15
  • Publication Date: 2014
  • Doi Number: 10.1186/1471-2474-15-191
  • Journal Name: BMC MUSCULOSKELETAL DISORDERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Fibromyalgia, Synaptosomal-associated protein 25 gene polymorphism, CHRONIC-FATIGUE-SYNDROME, COMORBIDITY, PREVALENCE, MECHANISMS, DISORDERS, DISEASE, STRESS, WOMEN, PAIN
  • Akdeniz University Affiliated: No

Abstract

Background: SNAP-25 protein is contributory to plasma membrane and synaptic vesicle fusions that are critical points in neurotransmission. SNAP-25 gene is associated with behavioral symptoms, personality and psychological disorders. In addition, SNAP-25 protein can be related to different neurotransmitter functions due to its association with vesicle membrane transition and fusion. This is important because neurologic, cognitive, and psychologic disorders in fibromyalgia syndrome (FMS) can be related to this function. This relationship may be enlightening for etiopathogenesis of FMS and treatment approaches. We aimed to study a SNAP-25 gene polymorphism, which is related to many psychiatric diseases, and FMS association in this prospective study.