CXCR5+CD8+ Follicular Cytotoxic T Cell Biology and Its Relationship with Diseases CXCR5+CD8+ Foliküler Sitotoksik T Hücrelerinin Biyolojisi ve Hastalıklar ile İlişkisi

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Ekinci N. S., Darbaş Ş., UÇAR F.

Turkish Journal of Immunology, cilt.10, sa.2, ss.48-55, 2022 (ESCI) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 10 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.4274/tji.galenos.2022.04796
  • Dergi Adı: Turkish Journal of Immunology
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE
  • Sayfa Sayıları: ss.48-55
  • Anahtar Kelimeler: autoimmune disease, B cell follicle, cancer, chronic viral infection, CXCR5+CD8+ T cells, germinal center
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Akdeniz Üniversitesi Adresli: Evet

Özet

© 2022, Turkish Society of Immunology. All rights reserved.CD8+ cytotoxic T (CD8+ T) cells are involved in the elimination of infected and cancerous cells. Functional cell groups of this immune system differentiate into effector and memory subsets to provide long-term protection. Although CD8+ T cells are rarely recognized as part of germinal center reactions, a new subset of the B cell follicle and germinal center, termed CXCR5+CD8+ follicular cytotoxic T (Tfc) cells, has recently been identified. These cells show a functional profile like CD4+ T follicular helper cells identified to activate B cells. While their functional mechanisms are largely similar, they control disease pathogenesis differently. Tfc cells check viral load during infection as well as support antibody-associated autoimmune disease progression. This review summarizes the phenotype, function, localization and function of Tfc cells and their relationship with diseases.