Midazolam and Tramadol-Paracetamol for Third Molar Pain Management
ANESTHESIA PROGRESS, cilt.25, sa.0016, ss.140-147, 2026 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 25 Sayı: 0016
- Basım Tarihi: 2026
- Doi Numarası: 10.2344/25-0016
- Dergi Adı: ANESTHESIA PROGRESS
- Derginin Tarandığı İndeksler: Scopus, MEDLINE, PubMed
- Sayfa Sayıları: ss.140-147
- Akdeniz Üniversitesi Adresli: Evet
Özet
Preemptive analgesia aims to reduce postoperative pain by administering analgesics before surgical stimuli. This study evaluates the efficacy of a fixed-dose oral tramadol-paracetamol combination in patients undergoing impacted third molar extraction under intravenous (IV) midazolam moderate sedation. A retrospective analysis was conducted on patients who underwent third molar surgery under IV midazolam moderate sedation. Participants were divided into 3 groups: preemptive tramadol-paracetamol, preemptive paracetamol, and no preemptive analgesia. Postoperative pain (visual analog scale), time to first analgesic intake, rescue analgesia requirement, and patient satisfaction were compared. The tramadol-paracetamol group had significantly lower visual analog scale scores and higher satisfaction than the other groups. Time to first analgesic intake was longer, and rescue analgesic use was reduced. No serious adverse events were observed. Within the scope of this comparison, preemptive oral tramadol-paracetamol administered under IV midazolam moderate sedation provided more effective postoperative pain control than paracetamol alone or no preemptive treatment in third molar surgery. This multimodal approach may help reduce additional analgesic requirements and enhance patient comfort in outpatient third molar procedures.Objective
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