Effects of some hematological parameters on whole blood tacrolimus concentration measured by two immunoassay-based analytical methods

AKBAS S. H., OZDEM S., CAGLAR S., TUNCER M., GURKAN A., YUCETIN L., ...Daha Fazla

CLINICAL BIOCHEMISTRY, cilt.38, sa.6, ss.552-557, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 6
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.clinbiochem.2005.02.011
  • Dergi Adı: CLINICAL BIOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.552-557
  • Anahtar Kelimeler: tacrolimus, MEIA II, EMIT, hematocrit, anemia, RDW, LIVER-TRANSPLANT RECIPIENTS, MICROPARTICLE ENZYME-IMMUNOASSAY, RENAL-TRANSPLANTATION, HEPATIC-CLEARANCE, FK506, PHARMACOKINETICS, ASSAY, BINDING, KIDNEY, ELISA
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Objectives: Tacrolimus (FK506) is a potent immunosuppressive drug used for prevention of rejection following transplantation. Several methods including immunoassays have been used for monitoring tacrolimus levels. The purpose of the present study was to compare the effects of various hematological parameters on whole blood tacrolimus concentrations which were measured with two different analytical methods, namely the microparticle enzyme immunoassay (MEIA II) and enzyme multiplied immunoassay technique (EMIT).