Effects of some hematological parameters on whole blood tacrolimus concentration measured by two immunoassay-based analytical methods

AKBAS, SADIKA; OZDEM, S; CAGLAR, S; TUNCER, M; GURKAN, A; YUCETIN, L; SENOL, YEŞİM; DEMIRBAS, A; Gultekin, MERAL; ERSOY, FETTAH; AKAYDIN, M

doi:10.1016/j.clinbiochem.2005.02.011

Effects of some hematological parameters on whole blood tacrolimus concentration measured by two immunoassay-based analytical methods

AKBAS S. H., OZDEM S., CAGLAR S., TUNCER M., GURKAN A., YUCETIN L., ...More

CLINICAL BIOCHEMISTRY, vol.38, no.6, pp.552-557, 2005 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 38 Issue: 6
Publication Date: 2005
Doi Number: 10.1016/j.clinbiochem.2005.02.011
Journal Name: CLINICAL BIOCHEMISTRY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.552-557
Keywords: tacrolimus, MEIA II, EMIT, hematocrit, anemia, RDW, LIVER-TRANSPLANT RECIPIENTS, MICROPARTICLE ENZYME-IMMUNOASSAY, RENAL-TRANSPLANTATION, HEPATIC-CLEARANCE, FK506, PHARMACOKINETICS, ASSAY, BINDING, KIDNEY, ELISA
Akdeniz University Affiliated: Yes

Abstract

Objectives: Tacrolimus (FK506) is a potent immunosuppressive drug used for prevention of rejection following transplantation. Several methods including immunoassays have been used for monitoring tacrolimus levels. The purpose of the present study was to compare the effects of various hematological parameters on whole blood tacrolimus concentrations which were measured with two different analytical methods, namely the microparticle enzyme immunoassay (MEIA II) and enzyme multiplied immunoassay technique (EMIT).